Two sample MR report
TMEM176A_Monocyte (Mono) against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 9 | 0.0761276 | 0.0544208 | 0.2045654 |
| Weighted median | 9 | 0.0236199 | 0.0093349 | 0.0113974 |
| Inverse variance weighted | 9 | 0.0162171 | 0.0073087 | 0.0264964 |
| Simple mode | 9 | 0.0255302 | 0.0136787 | 0.0989496 |
| Weighted mode | 9 | 0.0255302 | 0.0138786 | 0.1031183 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 2.576741 | 7 | 0.9212084 |
| Inverse variance weighted | 3.810930 | 8 | 0.8737663 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0341084 | 0.0307022 | 0.3032905 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001741 | 0 | TRUE | 0.2103607 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
